Taraxerone inhibits M1 polarization and alleviates sepsis-induced acute lung injury by activating SIRT1

Abstract Background Acute lung injury (ALI) is the most lethal disease associated with sepsis, and there is a lack of effective drug treatment. As the major cells of sepsis-induced ALI, macrophages polarize toward the proinflammatory M1 phenotype and secrete multiple inflammatory cytokines to accele...

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Bibliographic Details

Published in:	Chinese Medicine
Main Authors:	Lang Deng, Weixi Xie, Miao Lin, Dayan Xiong, Lei Huang, Xiaohua Zhang, Rui Qian, Xiaoting Huang, Siyuan Tang, Wei Liu
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Subjects:	Acute lung injury SIRT1 Taraxerone Oxidative stress Inflammation Macrophage polarization
Online Access:	https://doi.org/10.1186/s13020-024-01002-z