The senescent secretome drives PLVAP expression in cultured human hepatic endothelial cells to promote monocyte transmigration

Summary: Liver sinusoidal endothelial cells (LSEC) undergo significant phenotypic change in chronic liver disease (CLD), and yet the factors that drive this process and the impact on their function as a vascular barrier and gatekeeper for immune cell recruitment are poorly understood. Plasmalemma-ve...

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Bibliographic Details

Published in:	iScience
Main Authors:	Alex L. Wilkinson, Samuel Hulme, James I. Kennedy, Emily R. Mann, Paul Horn, Emma L. Shepherd, Kelvin Yin, Marco Y.W. Zaki, Gareth Hardisty, Wei-Yu Lu, Pia Rantakari, David H. Adams, Marko Salmi, Matthew Hoare, Daniel A. Patten, Shishir Shetty
Format:	Article
Language:	English
Published:	Elsevier 2023-10-01
Subjects:	Microenvironment Molecular biology Cell biology Omics Transcriptomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223020436