Computational modeling suggests binding-induced expansion of Epsin disordered regions upon association with AP2.
Intrinsically disordered regions (IDRs) are prevalent in the eukaryotic proteome. Common functional roles of IDRs include forming flexible linkers or undergoing allosteric folding-upon-binding. Recent studies have suggested an additional functional role for IDRs: generating steric pressure on the pl...
| Published in: | PLoS Computational Biology |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
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| Online Access: | https://doi.org/10.1371/journal.pcbi.1008474 |