An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

Abstract Coronaviruses have caused three major endemics in the past two decades. Alarmingly, recent identification of novel zoonotic coronaviruses that caused human infections suggests the risk of future coronavirus outbreak caused by spillover infection from animal reservoirs remains high. Therefor...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Huiping Shuai, Jingxin Qiao, Chaemin Yoon, Guo Zhang, Yuxin Hou, Xiaoyan Xia, Lei Wang, Xinyue Deng, Yifei Wang, Qingquan Li, Lianzhao Du, Yuanchen Liu, Minmin Zhou, Hoi Ting Wong, Jiaheng Hu, Huan Liu, Bingjie Hu, Dong Wang, Jingyi Su, Yuying Pan, Yongtao Ye, Yan Chen, Zhen Fang, Ziyi Xia, Yue Chai, Jialu Shi, Yang Wang, Tianrenzheng Zhu, Honglei Zhang, Shuofeng Yuan, Jie Zhou, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Chunfu Xu, Jian Lei, Shengyong Yang, Hin Chu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Online Access:	https://doi.org/10.1038/s41467-025-60832-z