Activation of the Innate Immune System in Brain-Dead Donors Can Be Reduced by Luminal Intestinal Preservation During Organ Procurement Surgery - A Porcine Model

Organs obtained from brain dead donors can have suboptimal outcomes. Activation of the innate immune system and translocation of intestinal bacteria could be causative. Thirty two pigs were assigned to control, brain death (BD), BD + luminal intestinal polyethylene glycol (PEG), and BD + luminal int...

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Bibliographic Details

Published in:	Transplant International
Main Authors:	Marc Gjern Weiss, Anne Marye de Jong, Helene Seegert, Niels Moeslund, Hanno Maassen, Camilla Schjalm, Eline de Boer, Henri Leuvenink, Tom Eirik Mollnes, Marco Eijken, Anna Krarup Keller, Gerard Dijkstra, Bente Jespersen, Søren Erik Pischke
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-10-01
Subjects:	brain dead donor luminal intestinal preservation C3a terminal complement complex lipopolysaccharide binding protein innate immune system
Online Access:	https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13569/full