A Novel Anti-BoNT/A Neutralizing Antibody Possessed Overlapped Epitope with SV2 and Had Prolonged Half-Life In Vivo

The C-terminus of the BoNT/A heavy chain (BoNT/AHC) mediates binding to its receptor, SV2, a critical step for toxicity. Antibody inhibition of this interaction enhances neuronal survival. We previously identified a functional anti-BoNT/AHC nanobody, HM. To extend its in vivo half-life, we designed...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Toxins
المؤلفون الرئيسيون:	Shangde Peng, Naijing Hu, Fenghao Peng, Huirong Mu, Zihan Yi, Cong Xing, Liang Zhang, Wen Hu, Xinyi Zhou, Yan Wen, Jiannan Feng, Chunxia Qiao
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2025-07-01
الموضوعات:	nanobody FcRn BoNT/AHC SV2 half-life
الوصول للمادة أونلاين:	https://www.mdpi.com/2072-6651/17/8/376