Personalized federated learning for predicting disability progression in multiple sclerosis using real-world routine clinical data

Abstract Early prediction of disability progression in multiple sclerosis (MS) remains challenging despite its critical importance for therapeutic decision-making. We present the first systematic evaluation of personalized federated learning (PFL) for 2-year MS disability progression prediction, lev...

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Bibliographic Details

Published in:	npj Digital Medicine
Main Authors:	Ashkan Pirmani, Edward De Brouwer, Ádám Arany, Martijn Oldenhof, Antoine Passemiers, Axel Faes, Tomas Kalincik, Serkan Ozakbas, Riadh Gouider, Barbara Willekens, Dana Horakova, Eva Kubala Havrdova, Francesco Patti, Alexandre Prat, Alessandra Lugaresi, Valentina Tomassini, Pierre Grammond, Elisabetta Cartechini, Izanne Roos, Cavit Boz, Raed Alroughani, Maria Pia Amato, Katherine Buzzard, Jeannette Lechner-Scott, Joana Guimarães, Claudio Solaro, Oliver Gerlach, Aysun Soysal, Jens Kuhle, Jose Luis Sanchez-Menoyo, Daniele Spitaleri, Tunde Csepany, Bart Van Wijmeersch, Radek Ampapa, Julie Prevost, Samia J. Khoury, Vincent Van Pesch, Nevin John, Davide Maimone, Bianca Weinstock-Guttman, Guy Laureys, Pamela McCombe, Yolanda Blanco, Ayse Altintas, Abdullah Al-Asmi, Justin Garber, Anneke Van der Walt, Helmut Butzkueven, Koen de Gans, Csilla Rozsa, Bruce Taylor, Talal Al-Harbi, Attila Sas, Cecilia Rajda, Orla Gray, Danny Decoo, William M. Carroll, Allan G. Kermode, Marzena Fabis-Pedrini, Deborah Mason, Angel Perez-Sempere, Mihaela Simu, Neil Shuey, Bhim Singhal, Marija Cauchi, Todd A. Hardy, Sudarshini Ramanathan, Patrice Lalive, Carmen-Adella Sirbu, Stella Hughes, Tamara Castillo Trivino, Liesbet M. Peeters, Yves Moreau
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Online Access:	https://doi.org/10.1038/s41746-025-01788-8