Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor

Abstract Semi-rational enzyme engineering is a powerful method to develop industrial biocatalysts. Profiting from advances in molecular biology and bioinformatics, semi-rational approaches can effectively accelerate enzyme engineering campaigns. Here, we present the optimization of a ketoreductase f...

Full description

Bibliographic Details

Published in:	Communications Chemistry
Main Authors:	Sumire Honda Malca, Nadine Duss, Jasmin Meierhofer, David Patsch, Michael Niklaus, Stefanie Reiter, Steven Paul Hanlon, Dennis Wetzl, Bernd Kuhn, Hans Iding, Rebecca Buller
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-02-01
Online Access:	https://doi.org/10.1038/s42004-024-01130-5