N-SREBP2 Provides a Mechanism for Dynamic Control of Cellular Cholesterol Homeostasis

Cholesterol is required to maintain the functional integrity of cellular membrane systems and signalling pathways, but its supply must be closely and dynamically regulated because excess cholesterol is toxic. Sterol regulatory element-binding protein 2 (SREBP2) and the ER-resident protein HMG-CoA re...

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Bibliographic Details

Published in:	Cells
Main Authors:	Tozen Ozkan-Nikitaras, Dominika J. Grzesik, Lisa E. L. Romano, J. P. Chapple, Peter J. King, Carol C. Shoulders
Format:	Article
Language:	English
Published:	MDPI AG 2024-07-01
Subjects:	cholesterol nucleus control ER
Online Access:	https://www.mdpi.com/2073-4409/13/15/1255