Genetic insights into alcohol-associated liver disease: integrative transcriptome-wide analysis identifies novel susceptibility genes

BackgroundAlcohol-associated liver disease (ALD) is a chronic condition influenced by both genetic and environmental factors. While GWAS has identified ALD-related loci (PNPLA3, MBOAT7, TM6SF2), underlying genetic mechanisms and therapeutic targets remain unclear.MethodsThis study utilized the FinnG...

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Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	Qianchang Wang, Zhe Wang, Minzhe Hu, Fangfeng Liu, Zhengjian Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	alcohol- associated liver disease (ALD) genome-wide association study (GWAS) transcriptome-wide association study (TWAS) multi-marker analysis of GenoMic annotation (MAGMA) Mendelian randomization (MR) drug enrichment analysis
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1623367/full