Knockout of NOS2 Promotes Adipogenic Differentiation of Rat MSCs by Enhancing Activation of JAK/STAT3 Signaling

Mesenchymal stromal cells (MSCs) are a heterogeneous population of cells that possess multilineage differentiation potential and extensive immunomodulatory properties. In mice and rats, MSCs produce nitric oxide (NO), as immunomodulatory effector molecule that exerts an antiproliferative effect on T...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Aiping Qin, Sheng Chen, Ping Wang, Xiaotao Huang, Yu Zhang, Lu Liang, Ling-Ran Du, De-Hua Lai, Li Ding, Xiyong Yu, Andy Peng Xiang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Subjects:	rat mesenchymal stromal cells NOS2 adipogenesis differentiation JAK/STAT3 signaling
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.638518/full