Near-perfect precise on-target editing of human hematopoietic stem and progenitor cells

Precision gene editing in primary hematopoietic stem and progenitor cells (HSPCs) would facilitate both curative treatments for monogenic disorders as well as disease modelling. Precise efficiencies even with the CRISPR/Cas system, however, remain limited. Through an optimization of guide RNA delive...

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Bibliographic Details
Published in:eLife
Main Authors: Fanny-Mei Cloarec-Ung, Jamie Beaulieu, Arunan Suthananthan, Bernhard Lehnertz, Guy Sauvageau, Hilary M Sheppard, David JHF Knapp
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-06-01
Subjects:
stem cell
hematopoiesis
genome editing
CRISPR
hematopoietic stem cell
leukemia
Online Access:https://elifesciences.org/articles/91288

Internet

https://elifesciences.org/articles/91288

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