Navoximod modulates local HSV-1 replication to reshape tumor immune microenvironment for enhanced immunotherapy via an injectable hydrogel

Abstract Oncolytic virotherapy can lead to tumor lysis and systemic anti-tumor immunity, but the therapeutic potential in humans is limited due to the impaired virus replication and the insufficient ability to overcome the immunosuppressive tumor microenvironment (TME). To solve the above problems,...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Qiuyu Zhuang, Binyu Zhao, Zhiwen Lin, Yuzhi Liang, Qingfu Zhao, Yunhao Wang, Naishun Liao, Haibin Tu, Youshi Zheng, Hengkai Chen, Yongyi Zeng, Da Zhang, Xiaolong Liu
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-06-01
Online Access:	https://doi.org/10.1038/s42003-023-04983-z