Promoter CpG methylation inhibits Krüppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells

Constitutive expression of human telomerase reverse transcriptase (hTERT) with DNA methylation of its promoter is a common phenomenon in tumor cells. We recently found that the transcriptional factor Krüppel-like factor 2 (KLF2) binds to the CpG sequences in the hTERT promoter and inhibits hTERT gen...

Full description

Bibliographic Details

Published in:	Biochemistry and Biophysics Reports
Main Authors:	Mariko Mizuguchi, Toshifumi Hara, Manami Yoshita-Takahashi, Takashi Kohda, Yuetsu Tanaka, Masataka Nakamura
Format:	Article
Language:	English
Published:	Elsevier 2021-07-01
Subjects:	Human telomerase reverse transcriptase (hTERT) Krüppel-like factor 2 (KLF2) DNA methylation Gene regulation T lymphocyte
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405580821000789