Stabilization of activated mast cells by ORAI1 inhibitor suppresses peanut-induced anaphylaxis and acute diarrhea

Mast cell (MC) activation triggered by immunoglobulin E (IgE)-antigen crosslinking involves intracellular Ca2+ influx through the ORAI1 channel, which precedes granule exteriorization and de novo synthesis of mediators. Pharmacologically suppressing MCs via the inhibition of the ORAI1 Ca2+ channel m...

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Bibliographic Details

Published in:	Pharmacological Research
Main Authors:	Gyeongseo Suk, Do Hoon Kwon, Axel Roers, Soman N. Abraham, Hae Woong Choi
Format:	Article
Language:	English
Published:	Elsevier 2023-10-01
Subjects:	Mast cell Allergy ORAI1 inhibitor Anaphylaxis
Online Access:	http://www.sciencedirect.com/science/article/pii/S1043661823002438