A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers

ABSTRACT Native-like HIV-1 envelope glycoprotein (Env) trimers, exemplified by the SOSIP design, are widely used as immunogens, analytical antigens, and for structural studies. These vaccine research and development programs require trimers that are based on multiple HIV-1 genotypes. While a wide ra...

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Bibliographic Details

Published in:	Journal of Virology
Main Authors:	Devidas N. Chaturbhuj, Kwinten Sliepen, Albert Cupo, Benjamin Steinberg, Simon Kazimierczyk, Tarek Munawar, Kyle Kramer, Anila Yasmeen, Thales G. Andrade, Wen-Hsin Lee, Lara van der Maas, Grace Gibson, Oscar Feliciano, Ivan del Moral Sanchez, Edith Schermer, Rhianna Bronson, Alison Benner, Madhu Prabhakaran, Rosemarie Mason, P. J. Klasse, Andrew B. Ward, Gabriel Ozorowski, Rogier W. Sanders, John P. Moore
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-09-01
Subjects:	HIV-1 SOSIP trimer gp41 heptad repeat Env glycoprotein
Online Access:	https://journals.asm.org/doi/10.1128/jvi.00913-25