Toll/interleukin-1 receptor (TIR) domain-containing proteins have NAD-RNA decapping activity

Abstract The occurrence of NAD+ as a non-canonical RNA cap has been demonstrated in diverse organisms. TIR domain-containing proteins present in all kingdoms of life act in defense responses and can have NADase activity that hydrolyzes NAD+. Here, we show that TIR domain-containing proteins from sev...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Xufeng Wang, Dongli Yu, Jiancheng Yu, Hao Hu, Runlai Hang, Zachary Amador, Qi Chen, Jijie Chai, Xuemei Chen
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-03-01
Online Access:	https://doi.org/10.1038/s41467-024-46499-y