Discovery of Hybrid Dual N-Acylhydrazone and Diaryl Urea Derivatives as Potent Antitumor Agents: Design, Synthesis and Cytotoxicity Evaluation

Based on the hybrid pharmacophore design concept, a novel series of dual diaryl urea and N-acylhydrazone derivatives were synthesized and evaluated for their in vitro cytotoxicity by the standard MTT assay. The pharmacological results indicated that most compounds exhibited moderate to excellent act...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Ping Gong, Hongyu Zhou, Di Wu, Nan Jiang, Qiang Huang, Xin Zhai
Format:	Article
Language:	English
Published:	MDPI AG 2013-03-01
Subjects:	diaryl ureas N-acylhydrazone cytotoxicity
Online Access:	http://www.mdpi.com/1420-3049/18/3/2904