Matrix metalloproteinase-12 by M2 macrophages induced epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyps.

Th2 inflammation and epithelial-mesenchymal transition (EMT) play crucial roles in the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to investigate the hypothesis that MMP-12, produced by M2 macrophages, induces EMT in nasal epithelial cells, thereby contribu...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Joo-Hoo Park, Jae-Min Shin, Hyun-Woo Yang, Tae Hoon Kim, Seung Hoon Lee, Ok Sarah Shin, Il-Ho Park
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2024-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0313097