Homocysteine activates T cells by enhancing endoplasmic reticulum-mitochondria coupling and increasing mitochondrial respiration

ABSTRACT Hyperhomocysteinemia (HHcy) accelerates atherosclerosis by increasing proliferation and stimulating cytokine secretion in T cells. However, whether homocysteine (Hcy)-mediated T cell activation is associated with metabolic reprogramming is unclear. Here, our in vivo and in vitro studies sho...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Protein & Cell
المؤلفون الرئيسيون: Juan Feng, Silin Lü, Yanhong Ding, Ming Zheng, Xian Wang
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Oxford University Press 2016-02-01
الموضوعات:
homocysteine
T cell
mitochondria
endoplasmic reticulum stress
الوصول للمادة أونلاين:http://link.springer.com/article/10.1007/s13238-016-0245-x

الانترنت

http://link.springer.com/article/10.1007/s13238-016-0245-x

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