Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents

Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). OP poisoning causes major cholinergic syndrome. Current medical counter-measures mitigate the acute effects but have limited action against OP-induced brain damage. Bioscavengers are appealing alternative thera...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Sofya V. Lushchekina, Lawrence M. Schopfer, Bella L. Grigorenko, Alexander V. Nemukhin, Sergei D. Varfolomeev, Oksana Lockridge, Patrick Masson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-03-01
Subjects:	bioscavenger organophosphorus compound computer design phosphotriesterase acetylcholinesterase butyrylcholinesterase
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2018.00211/full