Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

Sliding clamps are ring-shaped protein complexes that are integral to the DNA replication machinery of all life. Sliding clamps are opened and installed onto DNA by clamp loader AAA+ ATPase complexes. However, how a clamp loader opens and closes the sliding clamp around DNA is still unknown. Here, w...

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Bibliographic Details

Published in:	eLife
Main Authors:	Christl Gaubitz, Xingchen Liu, Joshua Pajak, Nicholas P Stone, Janelle A Hayes, Gabriel Demo, Brian A Kelch
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2022-02-01
Subjects:	sliding clamp loader AAA+ DNA replication
Online Access:	https://elifesciences.org/articles/74175