Biogenesis and regulation of the let-7 miRNAs and their functional implications

ABSTRACT The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis elegans, and its biological functions show a high level of evolutionary conservation from the nematode to the human. Unlike in C. elegans, higher animals have multiple isoforms of let-7 miRNAs; these isof...

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Bibliographic Details
Published in:Protein & Cell
Main Authors: Hosuk Lee, Sungwook Han, Chang Seob Kwon, Daeyoup Lee
Format: Article
Language:English
Published: Oxford University Press 2015-09-01
Subjects:
miRNA processing
miRNA biogenesis
let-7 family
TUTase
LIN28A/B
Online Access:http://link.springer.com/article/10.1007/s13238-015-0212-y

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