High expression of LncRNA HOTAIR is a risk factor for temozolomide resistance in glioblastoma via activation of the miR-214/β-catenin/MGMT pathway

Abstract HOX transcript antisense RNA (HOTAIR) is upregulated in glioblastoma (GBM) and associated with temozolomide (TMZ) resistance. However, the mechanisms underlying HOTAIR-mediated TMZ resistance remains poorly understood. HOTAIR expression in glioma-related public datasets and drug response es...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Tian Lan, Wei Quan, Dong-Hu Yu, Xi Chen, Ze-Fen Wang, Zhi-Qiang Li
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Subjects:
lncRNA HOTAIR
Temozolomide
Resistance
Β-catenin
Methotrexate
Online Access:https://doi.org/10.1038/s41598-024-77348-z

Internet

https://doi.org/10.1038/s41598-024-77348-z

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