Iron-responsive ZNF185 overexpression drives mitochondrial fission and endoplasmic reticulum stress via cytoskeletal remodeling in granulosa cells

Abstract Ovarian endometrioma (OMA), an estrogen-dependent gynecological disorder, is characterized by the presence of abundant free iron resulting from recurrent hemorrhage of endometrial cells within the cyst, which adversely affects ovarian function. However, the underlying mechanisms through whi...

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Bibliographic Details

Published in:	Cell Death Discovery
Main Authors:	Zhaoyue Huang, Yang You, Qi Qiu, Nan Dong, Xinye Hu, Meihong Cai, Yaoqiu Wu, Chunwei Cao, Qingxue Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-08-01
Online Access:	https://doi.org/10.1038/s41420-025-02719-y