Hemisynthesis and Biological Evaluation of Cinnamylated, Benzylated, and Prenylated Dihydrochalcones from a Common Bio-Sourced Precursor

Several families of naturally occurring <i>C</i>-alkylated dihydrochalcones display a broad range of biological activities, including antimicrobial and cytotoxic properties, depending on their alkylation sidechain. The catalytic Friedel–Crafts alkylation of the readily available aglycon...

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Bibliographic Details

Published in:	Antibiotics
Main Authors:	Anne Ardaillou, Jérôme Alsarraf, Jean Legault, François Simard, André Pichette
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Subjects:	antibacterial Brønsted acid catalysis dihydrochalcone Friedel–Crafts alkylation hemisynthesis natural products
Online Access:	https://www.mdpi.com/2079-6382/10/6/620