TNF-α/IL-1β-licensed hADSCs alleviate cholestatic liver injury and fibrosis in mice via COX-2/PGE2 pathway

Abstract Background Adipose tissue-derived stem cell (ADSC) transplantation has been shown to be effective for the management of severe liver disorders. Preactivation of ADSCs enhanced their therapeutic efficacy. However, these effects have not yet been examined in relation to cholestatic liver inju...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Xiaoyu Luan, Peng Chen, Yaxin Li, Xinying Yuan, Longyu Miao, Pengyu Zhang, Qilong Cao, Xiaomin Song, Guohu Di
Format:	Article
Language:	English
Published:	BMC 2023-04-01
Subjects:	Adipose tissue-derived stem cells TNF-α/IL-1β pretreatment Bile duct ligation Liver fibrosis COX-2/PGE2 pathway
Online Access:	https://doi.org/10.1186/s13287-023-03342-3