Circadian rhythm disturbances in Alzheimer’s disease: insights from plaque-free and plaque-burdened stages in APPSWE/PS1dE9 mice

Abstract Background Disruptions in circadian rhythms are commonly observed in patients with Alzheimer’s disease (AD) and could potentially accelerate the progression of the condition. However, the relationship between circadian rhythm disruptions and AD development, as well as the mechanisms involve...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Huijia Yang, Long Niu, Lulu Tian, Yiying Hu, Cheng Cheng, Song Li, Weidong Le
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Subjects:	Alzheimer’s disease Circadian rhythm Sleep-wake cycle Clock gene Suprachiasmatic nucleus
Online Access:	https://doi.org/10.1186/s13195-025-01724-8