Selective Enrichment of Hypermethylated DNA by a Multivalent Binding Platform

Abstract The preselection of hypermethylated DNA (hmDNA) from liquid biopsy samples is key to enable early‐stage cancer diagnostics. Due to limited selectivity of the existing preselection approaches, however, wide integration in the clinic is currently prohibited. Here, it is argued that an affinit...

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Bibliographic Details

Published in:	Advanced Materials Interfaces
Main Authors:	Ruben W. Kolkman, Loes I. Segerink, Jurriaan Huskens
Format:	Article
Language:	English
Published:	Wiley-VCH 2022-12-01
Subjects:	hypermethylated DNA methyl binding domain (MBD) proteins multivalency superselectivity
Online Access:	https://doi.org/10.1002/admi.202201557