EGFR-targeting polydopamine nanoparticles co-loaded with 5-fluorouracil, irinotecan, and leucovorin to potentially enhance metastatic colorectal cancer therapy

Abstract Despite all prevention programs, many cases of colorectal cancer (CRC) are diagnosed when they have already metastasized. Herein, chemotherapy is required, and combination of 5-fluorouracil, irinotecan, and leucovorin (FOLFIRI) is one of the first-line treatments chosen. However, it is so t...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Rania Djermane, Celia Nieto, Milena A. Vega, Eva M. Martín del Valle
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-11-01
Subjects:	Polydopamine nanoparticles Colorectal cancer 5-Fluorouracil Irinotecan Leucovorin Epidermal growth factor receptor
Online Access:	https://doi.org/10.1038/s41598-024-80879-0