The antimicrobial peptide Angie 5 inhibits TcdA and TcdB from Clostridioides difficile

Abstract Clostridioides (C.) difficile is a spore-forming, toxin-producing nosocomial human gut pathogen and a causative agent of gastrointestinal infections, leading to mild to severe diarrhea. Severe C. difficile infections (CDI) can cause life-threatening conditions, such as pseudomembranous coli...

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Bibliographic Details

Published in:	Cellular and Molecular Life Sciences
Main Authors:	Stefanie Lietz, Lena-Marie Sokolowski, Katrin Lindner, Armando A. Rodríguez, Ludger Ständker, Verena Vogel, Barbara Spellerberg, Steffen Stenger, Daniel Alpízar-Pedraza, Katharina Ernst, Panagiotis Papatheodorou, Holger Barth
Format:	Article
Language:	English
Published:	Springer 2025-06-01
Subjects:	Clostridioides difficile TcdA TcdB Toxin inhibitor Endogenous proteins Antimicrobial peptides
Online Access:	https://doi.org/10.1007/s00018-025-05799-2