How do neurons age? A focused review on the aging of the microtubular cytoskeleton

Aging is the leading risk factor for Alzheimer's disease and other neurodegenerative diseases. We now understand that a breakdown in the neuronal cytoskeleton, mainly underpinned by protein modifications leading to the destabilization of microtubules, is central to the pathogenesis of Alzheimer...

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Bibliographic Details

Published in:	Neural Regeneration Research
Main Authors:	Brad Richardson, Thomas Goedert, Shmma Quraishe, Katrin Deinhardt, Amritpal Mudher
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2024-01-01
Subjects:	age-related changes; aging; cytoskeleton; microtubules; neuronal morphology
Online Access:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=9;spage=1899;epage=1907;aulast=