Diprovocim protects against the radiation-induced damage via the TLR2 signaling pathway

Abstract Severe ionizing radiation (IR) causes the acute lethal damage of hematopoietic system and gastrointestinal tract. By establishing a radiation injury model, we found that Diprovocim, a TLR2 agonist, protected mice against the lethal damage of hematopoietic system and gastrointestinal tract....

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Bibliographic Details

Published in:	Molecular Medicine
Main Authors:	Duo Fang, Hainan Zhao, Lu Pei, Kai Jiang, Yuhan Gan, Xuanlu Zhai, Liao Zhang, Ying Cheng, Cong Liu, Jicong Du, Fu Gao
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Subjects:	Ionizing radiation-induced injury Intestinal stem cells Diprovocim TLR2 SOX9
Online Access:	https://doi.org/10.1186/s10020-025-01198-2