The Synergistic Antitumor Effect of Decitabine and Vorinostat Combination on HepG2 Human Hepatocellular Carcinoma Cell Line via Epigenetic Modulation of Autophagy–Apoptosis Molecular Crosstalk

Hepatocellular carcinoma (HCC) is a worldwide health issue. Epigenetic alterations play a crucial role in HCC tumorigenesis. Using epigenetic modulators for HCC treatment confers a promising therapeutic effect. The aim of this study was to explore the effect of a decitabine (DAC) and vorinostat (VOR...

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Bibliographic Details

Published in:	Current Issues in Molecular Biology
Main Authors:	Basant M. Salama, Maged W. Helmy, Hosny Fouad, Marium M. Shamaa, Maha E. Houssen
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Subjects:	DNA methyltransferase inhibitors decitabine histone deacetylase inhibitors vorinostat apoptosis autophagy
Online Access:	https://www.mdpi.com/1467-3045/45/7/375