The viral context instructs the redundancy of costimulatory pathways in driving CD8+ T cell expansion

Signals delivered by costimulatory molecules are implicated in driving T cell expansion. The requirements for these signals, however, vary from dispensable to essential in different infections. We examined the underlying mechanisms of this differential T cell costimulation dependence and found that...

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Bibliographic Details
Published in:eLife
Main Authors: Suzanne PM Welten, Anke Redeker, Kees LMC Franken, Jennifer D Oduro, Ferry Ossendorp, Luka Čičin-Šain, Cornelis JM Melief, Peter Aichele, Ramon Arens
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Subjects:
t cell
costimulation
viral infection
Online Access:https://elifesciences.org/articles/07486

Internet

https://elifesciences.org/articles/07486

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