Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity

Systemic treatment with the active transcription inhibitor lurbinectedin aims at inducing tumor cell death in hyperproliferative neoplasms. Here we show that cell death induced by lurbinectedin reinstates and enhances systemic anticancer immune responses. Lurbinectedin treatment showed traits of imm...

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Bibliographic Details

Published in:	OncoImmunology
Main Authors:	Wei Xie, Sabrina Forveille, Kristina Iribarren, Allan Sauvat, Laura Senovilla, Yan Wang, Juliette Humeau, Maria Perez-Lanzon, Heng Zhou, Juan F. Martínez-Leal, Guido Kroemer, Oliver Kepp
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-11-01
Subjects:	anticancer immunity immunogenic cell death checkpoint blockade tumor clearance
Online Access:	http://dx.doi.org/10.1080/2162402X.2019.1656502