Accessing a hidden conformation of the maltose binding protein using accelerated molecular dynamics.

Periplasmic binding proteins (PBPs) are a large family of molecular transporters that play a key role in nutrient uptake and chemotaxis in Gram-negative bacteria. All PBPs have characteristic two-domain architecture with a central interdomain ligand-binding cleft. Upon binding to their respective li...

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Bibliographic Details

Published in:	PLoS Computational Biology
Main Authors:	Denis Bucher, Barry J Grant, Phineus R Markwick, J Andrew McCammon
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-04-01
Online Access:	https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002034&type=printable