Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury

Abstract Progranulin (PGRN), which is produced in neurons and microglia, is a neurotrophic and anti-inflammatory glycoprotein. Human loss-of-function mutations cause frontotemporal dementia, and PGRN knockout (KO) mice are a model for dementia. In addition, PGRN KO mice exhibit severe phenotypes in...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Sudena Wang, Marc-Philipp Weyer, Regina Hummel, Annett Wilken-Schmitz, Irmgard Tegeder, Michael K. E. Schäfer
Format:	Article
Language:	English
Published:	BMC 2024-10-01
Subjects:	Progranulin Traumatic brain injury Neuropathology Neuroprotection Neuroinflammation Microglia
Online Access:	https://doi.org/10.1186/s12974-024-03249-7