Conditional knockout mouse model reveals a critical role of peroxiredoxin 1 in oral leukoplakia carcinogenesis

Peroxiredoxin 1 (Prx1) is an antioxidant protein that may promote the carcinogenesis in oral leukoplakia (OLK). To investigate the effect of Prx1 on the oral mucosal epithelium of OLK, we generated a Prx1 conditional knockout (cKO) mouse model. The mRNA and gRNA were generated using the clustered re...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Lingyu Li, Jing Li, Yunping Lu, Wenjing Li, Jing Yang, Min Wang, Congcong Miao, Zhenchuan Tian, Min Zhang, Xiaofei Tang
Format:	Article
Language:	English
Published:	Elsevier 2024-05-01
Subjects:	Peroxiredoxin 1 Oral leukoplakia CRISPR-Cas systems Gene knockout technique
Online Access:	http://www.sciencedirect.com/science/article/pii/S240584402407258X