Oxidative stress and regulation of adipogenic differentiation capacity by sirtuins in adipose stem cells derived from female patients of advancing age

Abstract Patient age is critical for mesenchymal stem cell quality and differentiation capacity. We demonstrate that proliferation and adipogenic capacity of subcutaneous adipose stem cells (ASCs) from female patients declined with advanced age, associated with reduction in cell nucleus size, increa...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Anne Bernhardt, Alan Jamil, Md. Tanvir Morshed, Pia Ponnath, Veronika Gille, Nadine Stephan, Heinrich Sauer, Maria Wartenberg
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-08-01
Subjects:	Adipose stem cells Oxidative stress Adipogenesis Sirtuins
Online Access:	https://doi.org/10.1038/s41598-024-70382-x