Machine learning-based detection of adventitious microbes in T-cell therapy cultures using long-read sequencing

ABSTRACT Assuring that cell therapy products are safe before releasing them for use in patients is critical. Currently, compendial sterility testing for bacteria and fungi can take 7–14 days. The goal of this work was to develop a rapid untargeted approach for the sensitive detection of microbial co...

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Bibliographic Details

Published in:	Microbiology Spectrum
Main Authors:	James P. B. Strutt, Meenubharathi Natarajan, Elizabeth Lee, Denise Bei Lin Teo, Wei-Xiang Sin, Ka-Wai Cheung, Marvin Chew, Khaing Thazin, Paul W. Barone, Jacqueline M. Wolfrum, Rohan B. H. Williams, Scott A. Rice, Stacy L. Springs
Format:	Article
Language:	English
Published:	American Society for Microbiology 2023-10-01
Subjects:	T-cells adventitious agents machine learning sterility
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.01350-23