The Aβ42:Aβ40 ratio modulates aggregation in beta-amyloid oligomers and drives metabolic changes and cellular dysfunction

The pathophysiological role of Aβ42 oligomers in the onset of Alzheimer’s disease (AD) is heavily disputed, pivoting research toward investigating mixed oligomers composed of Aβ42 and Aβ40, which is more abundant but less aggregation-prone. This study investigates Aβ42:Aβ40 oligomers in different ra...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Annika Haessler, Stefanie Gier, Nathalie Jung, Maike Windbergs
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Subjects:	Alzheimer’s disease Aβ oligomers blood–brain barrier Raman microscopy lipid droplets Aβ42:Aβ40
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2024.1516093/full