Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS

Abstract Importin β-superfamily nuclear import receptors (NIRs) mitigate mislocalization and aggregation of RNA-binding proteins (RBPs), like FUS and TDP-43, which are implicated in neurodegenerative diseases. NIRs potently disaggregate RBPs by recognizing their nuclear localization signal (NLS). Ho...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Miyuki Hayashi, Amandeep Girdhar, Ying-Hui Ko, Kevin M. Kim, Jacquelyn A. DePierro, Joseph R. Buchler, Nikhita Arunprakash, Aditya Bajaj, Gino Cingolani, Lin Guo
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-09-01
Online Access:	https://doi.org/10.1038/s41467-024-52151-6