Acquired immunostimulatory phenotype of migratory CD103+ DCs promotes alloimmunity following corneal transplantation

After transplantation, Th1-mediated immune rejection is the predominant cause of graft failure. Th1 cell sensitization occurs through complex and context-dependent interaction among antigen-presenting cell subsets, particularly CD11b+ DCs (DC2) and CD103+ DCs (DC1). This interaction necessitates fur...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Tomás Blanco, Hayate Nakagawa, Aytan Musayeva, Mark Krauthammer, Rohan Bir Singh, Akitomo Narimatsu, Hongyan Ge, Sara I. Shoushtari, Reza Dana
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2024-10-01
Subjects:	Immunology Ophthalmology
Online Access:	https://doi.org/10.1172/jci.insight.182469