The CDR3 region as the major driver of TREM-1 interaction with its ligands, an in silico characterization

The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor heavily investigated in infectious and non-infectious diseases. Because of its role in amplifying inflammation, TREM-1 has been explored as a diagnostic/prognostic biomarker. Further, as the receptor has...

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Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Amanda de Oliveira Matos, Pedro Henrique dos Santos Dantas, Mike Telemaco Contreras Colmenares, Geraldo Rodrigues Sartori, Marcelle Silva-Sales, João Herminio Martins Da Silva, Bruno Junior Neves, Carolina Horta Andrade, Helioswilton Sales-Campos
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Subjects:	TREM-1 Binding domain CDR3 TREM-1 ligands Pattern recognition receptor
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037023001617