WRN helicase structural flexibility showcased through fragment-based lead discovery of inhibitors

WRN helicase has been recognized as a promising synthetic lethal target for therapeutic intervention in cancers characterized by microsatellite instability-high (MSI-H) and mismatch repair deficiency (MMRd). However, the search for effective helicase inhibitors poses significant challenges, as high-...

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發表在:	Structural Dynamics
Main Authors:	Rachel L Palte, Mihir Mandal, Justyna Sikorska, Artjohn Villafania, Meredith M Rickard, Robert Bauer, Xiaomei Chai, Jiafang He, Zahid Hussain, Markus Koglin, Hannah B MacDonald, My S Mansueto, Klaus Maskos, Joey L Methot, Aileen Soriano, Marcel J Tauchert, Sriram Tyagarajan, Minjia Zhang, Daniel J Klein, Jacqueline D Hicks, David G McLaren, Sandra B Gabelli, Daniel F Wyss
格式:	Article
語言:	英语
出版:	AIP Publishing LLC and ACA 2025-10-01
在線閱讀:	https://pubs.aip.org/aca/sdy/article-pdf/12/5_Supplement/A110/20775225/a110_1_4.0000901.pdf