Engineered supercooling systems for enhanced long-term preservation of large-volume red blood cells in commercial blood bags

Abstract Reducing cell metabolism by lowering the storage temperature is an important method to improve the quality of stored RBCs and prolong the stored shelf life of RBCs. Traditional cryopreservation suffers from limitations such as tedious cytotoxic cryoprotectants (CPA) loading, unloading and i...

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Bibliographic Details

Published in:	Journal of Biological Engineering
Main Authors:	Qi Liu, Shichun Wang, Jie Yan, Ronghua Diao, Haishui Huang, Feng Xu, Chunyan Yao
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Subjects:	Supercooling Preservation Red Blood Cells Blood Bags Metabolic Stability Oxidative Stress
Online Access:	https://doi.org/10.1186/s13036-025-00510-2