The effect of down-regulation of Smad3 by RNAi on hepatic stellate cells and a carbon tetrachloride-induced rat model of hepatic fibrosis

Searching for effective Smad3 gene-based gene therapies for hepatic fibrosis, we constructed siRNA expression plasmids targeting the rat Smad3 gene and then delivered these plasmids into hepatic stellate cells (HSCs). The effect of siRNAs on the mRNA levels of Smad2, Smad3, Smad4, and collagens I-&a...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Brazilian Journal of Medical and Biological Research
المؤلفون الرئيسيون:	Z.R. Wang, J.H. Wang, C.L. Hu, W.G. Cao, X.J. Shen, M.Y. Wu, L. Shen, S.L. Wu
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Associação Brasileira de Divulgação Científica 2011-02-01
الموضوعات:	Smad3 SiRNA Hepatic fibrosis Carbon tetrachloride
الوصول للمادة أونلاين:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200002