Rhabdomyosarcoma Cells Produce Their Own Extracellular Matrix With Minimal Involvement of Cancer-Associated Fibroblasts: A Preliminary Study

BackgroundThe interplay between neoplastic cells and surrounding extracellular matrix (ECM) is one of the determinant elements for cancer growth. The remodeling of the ECM by cancer-associated fibroblasts (CAFs) shapes tumor microenvironment by depositing and digesting ECM proteins, hence promoting...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Stefania D’Agostino, Lucia Tombolan, Mattia Saggioro, Chiara Frasson, Elena Rampazzo, Stefania Pellegrini, Francesca Favaretto, Carlo Biz, Pietro Ruggieri, Piergiorgio Gamba, Paolo Bonvini, Sanja Aveic, Roberto Giovannoni, Michela Pozzobon
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-01-01
Subjects:	rhabdomyosarcoma cancer-associated fibroblasts tumor microenvironment extracellular matrix proteins stroma
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2020.600980/full