The construction of in vitro nasal cavity-mimic M-cell model, design of M cell-targeting nanoparticles and evaluation of mucosal vaccination by nasal administration

In order to better evaluate the transport effect of nanoparticles through the nasal mucosa, an in vitro nasal cavity-mimic model was designed based on M cells. The differentiation of M cells was induced by co-culture of Calu-3 and Raji cells in invert model. The ZO-1 protein staining and the transpo...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Xiaotong Yang, Xianchun Chen, Ting Lei, Lin Qin, Yang Zhou, Chuan Hu, Qingfeng Liu, Huile Gao
Format:	Article
Language:	English
Published:	Elsevier 2020-06-01
Subjects:	M cells In vitro Cell model iRGD peptide Nasal administration Mucosal vaccination
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383520300496